Study: Predictive Accuracy of the Quick Sepsis-Related Organ Failure Assessment Score in Brazil: A Prospective Multicenter Study
Study Predictive Accuracy of the Quick Sepsis-Related Organ Failure Assessment Score in Brazil Wide.jpg

Our colleagues from the Latin American Sepsis Institute would like to draw your attention to an important contribution to the literature around qSOFA.

When the Sepsis-3 definition was published, a new retrospectively-derived tool was proposed to help identify patients with infection at higher risk of deterioration – the 'quick-SOFA' or qSOFA score. Although it was intended only as a risk prediction score, many institutions are now incorrectly using it as a screening tool for sepsis.

LASI, concerned about the potential for low sensitivity of qSOFA, conducted a prospective observational study to evaluate it in Brazil. This study has now been published in a high-impact journal, the American Journal of Respiratory and Critical Care Medicine (AJRCCM).

This is a robust, prospective, multicenter study across 74 Brazilian hospitals, including more than 10,000 patients. It shows that qSOFA has a low sensitivity for the prediction of mortality and suggests that its use as a screening tool for patients with suspected sepsis may result in a high proportion of patients being missed - meaning for many that they ultimately would die. The authors also propose alternative tools to improve the sensitivity of qSOFA when screening for sepsis.

Marvin Zick
Sepsis Awareness Posters, Pocket Cards, and WSD Flyer Now Updated with New Data from GBD Sepsis Study
Banner copy.jpg

On January 16th, the Global Burden of Disease Sepsis Study revealed staggering new data on the incidence and mortality of sepsis globally. After updating our English WSD Infographics the week after, we are now happy to report that our Sepsis Awareness Posters, our Pocket Cards, and our WSD Flyer have been updated with the new numbers as well - they are available for you to download in our WSD Toolkit Section.

Additionally, the design of Sepsis Awareness Posters has been improved and is now in line with our 2020 WSD Infographics. Over the coming weeks and months, we plan to translate more of our infographics and release an updated fact sheet on sepsis.

Please contact us to give feedback on the updated material so we can improve it even further. Lastly, please consider donating to support the ongoing development of our free sepsis awareness resources – they are and always will be free to download and use. Thanks!

Marvin Zick
Invitation to the WSD Supporter Meeting on March 24th at the 40th ISICEM in Brussels, Belgium
IMG_3295 Kopie.jpg

Update March 9th, 2020: The 40th ISICEM has been postponed to September 15th to 18th. Our WSD Supporter Meeting is canceled until further notice.

Original article:

Our next WSD Supporter Meeting will take place on March 24th, 2020 at the International Symposium of Intensive Care and Emergency Medicine in Brussels. The main topics will be the GSA activities in 2019 and 2020, the progress of the implementation of the WHO Resolution on Sepsis, our regional sepsis alliances, and an update on local sepsis activities. The preliminary agenda is available below.

If you are in Brussels in March, we encourage you to participate – we are looking forward to connecting with you and hearing your ideas and suggestions to continue to raise awareness for sepsis worldwide.

  • Tuesday, March 24th, 2020

  • 12:15 to 13:45h (lunch break of ISICEM)

  • Meeting Room: 211/212

  • Snacks will be provided

  • Participation is free of charge and open to everyone

Marvin Zick
The 2030 World Sepsis Declaration - Goals and Key Targets for the Next Decade
2030WorldSepsisDeclarationWide.jpg

Following on the heels of the Global Burden of Disease Study revealing staggering new numbers on the global incidence and mortality of sepsis, we have updated our World Sepsis Declaration.

The new 2030 World Sepsis Declaration sets our goals and key targets for the next decade and serves as the north star of our global efforts, jointly with the WHO Resolution on Sepsis. It includes the following key targets to be achieved until 2030:

  1. The Global Incidence of Sepsis Will Decrease Through Strategies to Prevent Infection

  2. Governments Will Ensure That the Three Pillars of Infection Management Be Considered Jointly at the Policy Level

  3. Sepsis Survival Will Increase for Children (Including Neonates) and Adults in All Countries Through the Promotion and Adoption of Early Recognition Systems and Standardized Emergency Treatment

  4. Access to Appropriate Rehabilitation Services Will Have Improved for All Patients Worldwide

  5. Public and Professional Understanding and Awareness of Sepsis Will Improve

  6. The Measurement of the Global Burden of Sepsis and the Impact of Sepsis Control and Management Interventions Will Have Improved Significantly

If you or your organization supports these goals, we encourage you to virtually sign the World Sepsis Declaration now.

Marvin Zick
Invitation: 3rd Annual Meeting of the European Sepsis Alliance, March 23rd, 2020, Brussels
3rd annual meeting banner.jpg

Update March 12th: The meeting will take place completely online - livestreamed to you at europeansepsisalliance.org/annualmeeting - more info here.

Update March 4th: The timing of our event has changed slightly to due logistic reasons - we now start at 13:00, with a welcome lunch and registration at 12:15. The new timing is reflected in the new program below. Sorry for any inconvenience.

Original article:

On Monday, March 23rd, 2020, the European Sepsis Alliance will hold its 3rd Annual Meeting in Brussels, Belgium. You are hereby cordially invited to join us and many prestigious speakers at this important event.

The event will provide an opportunity to hear from policymakers about how public policy can tackle sepsis, listen to updates on the fight against sepsis in countries who have undertaken significant steps, and discuss with survivors and experts what it takes to fight sepsis effectively on the national, community, and healthcare facility level.

Event Details:

  • 3rd Annual Meeting of the European Sepsis Alliance

  • Monday, March 23rd, 2020, 12:15 to 16:15h

  • Permanent Representation of the Federal Republic of Germany to the European Union in Brussels (Rue Jacques de Lalaing 8-14, 1040 Brussels, Metro: Arts-Loi / Maalbeek)

Due to limited seating capacity, please sign up at your earliest convenience. We look forward to welcoming you at the event and have a fruitful discussion, in order to foster the fight against sepsis in Europe together!

The European Sepsis Alliance was founded under the patronage of the European Commissioner for Health and Food Safety, Vytenis Andriukaitis, at our event “Sepsis - A Call to EU Action” in March 2018 and is one of our regional sepsis alliances.

Marvin Zick
The 2020 World Sepsis Day Infographics: Brand-New Design and Including the Findings from the Global Burden of Disease Sepsis Study
2020 WSD Infographics Wide.jpg

We are thrilled to release our new 2020 Infographics today - with a brand-new design that is more mature, easier to read and comprehend, and, more importantly, including the findings from the Global Burden of Disease Study released in The Lancet last week.

As always, the new infographics are a quick and free download in our World Sepsis Day Toolkit Section – please download them and use them as you see fit, on your social media channels, printed at your events, and everywhere in between. They are available only in English for now, but we are working hard to translate them in the coming weeks.

There is a total of 21 infographics, nine on sepsis itself, ranging from symptoms, sources, prevention, risk groups, to physiology, post-sepsis symptoms, and more. Additionally, there are two on hand-washing, and ten more highlighting the relationship to other World Health Days, such as World AIDS Day, World Hepatitis Day, and more. The infographics are available as images (.jpg), as well as optimized for print (.pdf).

We put a lot of thought and time into the new infographics – please contact us to give feedback so we can improve them even further. Lastly, please consider donating to support the ongoing development of our free sepsis awareness resources – thanks!

Marvin Zick
Shaun’s Sepsis Story – Loved Father and Grandfather Taken by Sepsis in Less Than 48h
Shaun O'Connor Sepsis Wide.jpg

Our dad came down with, what he thought was, the flu. He spent a few days at home trying to kick the sickness. He complained of fever, chills, retching, diarrhea, and waking up in a pool of sweat. He eventually ended up in the local hospital ER due to the symptoms not getting any better. The hospital did not know what was wrong with him but continued to monitor him overnight. I talked to him on the phone while he was there, and he revealed that his potassium levels were critically low, and he was unable to urinate. Little did I know that this would be the last time I would speak with him.

During the early morning hours of the next day, he went into cardiac arrest and the doctors spent 20 minutes getting him stable enough to fly to Reno, Nevada. At this point, our family was notified by one of his nurses that we needed to get to Reno immediately. He went into cardiac arrest for a second time upon arrival to the ICU. He was stabilized, put into a medically induced coma, and placed on a respirator. His fever was 105 degrees, yet his fingers were ice cold. He completed a round of dialysis to remove some of the toxins from his blood. It was then that we were taken into “the room” at the hospital. The room in which we were informed that my dad would not make it through the night. News you never want to hear. We watched as my dad’s body slowly shut down. His kidneys, heart, and lungs were all shutting down. He had low blood pressure and an elevated heart rate. He was maxed out on all medications. We were told it may be best to sign a DNR (do not resuscitate) because they would just end up breaking his ribcage trying to bring him back again and they were unsure if he was still in there as far as brain activity. He passed away the morning of October 13, 2017.

The doctors noted ‘septic shock of an unknown cause’ and ‘multi-organ failure’ on his death certificate. They mentioned that is was a gastrointestinal infection that lead to sepsis. We never found out the actual bacteria (or other agent) that caused the septic shock.
The hours leading up to that morning are engrained into my memory. Memories that I can replay clear as day. And even now, all I am left with is constant thoughts of “what if” and confusion of how something like this could’ve happened. There is nothing I wouldn’t give to bring him back.

I want people to be aware and spread knowledge. Know the signs of sepsis. Get immediate medical help. Don’t let sepsis take the life of another loved one.

In loving memory of our dad, Shaun O’Connor. You are so missed.


The article above was written by Caitlin and Brianne O’Connor, Shaun’s daughters, and is shared here with their explicit consent. The views in the article do not necessarily represent those of the Global Sepsis Alliance. They are not intended or implied to be a substitute for professional medical advice. The whole team here at the GSA and World Sepsis Day wishes to thank Caitlin and Brianne for sharing her father’s story and for fighting to raise awareness for sepsis.


Marvin Zick
The Lancet: Sepsis Associated with 1 in 5 Deaths Worldwide, Double Prior Estimates – Children and Poor Regions Hit Hardest
Sepsis 48.9 million cases 11 million deaths wide.jpg

Twice as many people are dying from sepsis worldwide than previously estimated, according to a groundbreaking study by an international team of scientists published in The Lancet today. Among them are a disproportionately high number of children in poor areas.

This study, the most comprehensive clinical study on sepsis to date, revealed 48.9 million cases of sepsis in 2017 and 11 million deaths. 1 in 5 deaths globally are associated with sepsis. Sepsis arises when the body’s response to an infection injures its own tissues and organs. It may lead to shock, multi-organ failure, and death – especially if not recognized early and treated promptly. For sepsis survivors, it can create lifelong disabilities and suffering.

It was found that about 85% of sepsis cases occurred in low- or middle-income countries – especially in Sub-Saharan Africa, the South Pacific islands, and South, East, and Southeast Asia. While sepsis incidence is higher among females than males, more than 40% of all cases are occurring in children under 5.

 
I’ve worked in rural Uganda, and sepsis is what we saw every single day. Watching a baby die of a disease that could have been prevented with basic public health measures really sticks with you. I want to contribute to solving this tragedy, so I participate in research on sepsis. However, how can we know if we’re making progress if we don’t even know the size of the problem? If you look at any top 10 list of deaths globally, sepsis is not listed because it hasn’t been counted.
— Lead Author Kristina E. Rudd, M.D., M.P.H., Assistant Professor at Pitt's Department of Critical Care Medicine
 

For their analysis, Rudd and colleagues leveraged the Global Burden of Disease Study, a comprehensive epidemiological analysis coordinated by the Institute for Health Metrics and Evaluation (IMHE) at the University of Washington School of Medicine. Previous global estimates for sepsis relied upon hospital databases from select middle- and high-income countries, making them severely limited and prone to overlooking the occurrence outside of the hospital, especially in low-income countries.

 
We are alarmed to find sepsis deaths are much higher than previously estimated, especially as the condition is both preventable and treatable. We need renewed focus on sepsis prevention among newborns and on tackling antimicrobial resistance, an important driver of the condition.
— Senior Author Mohsen Naghavi, M.D., Ph.D., M.P.H., Professor of health metrics sciences at IHME at the University of Washington School of Medicine
 

Although the number of cases are much higher than previously estimated, it is important to note that great international and collaborative work has been done worldwide in the past decades to fight sepsis. These efforts are conveyed in the study which examined annual sepsis incidence and mortality trends from 1990 to 2017. The study found that rates are actually decreasing. In 1990, there were an estimated 60.2 million sepsis cases and 15.7 million deaths, compared to the 48.9 million cases and 11 million deaths in 2017. However, the study highlights we still have a long way to go in the global fight against sepsis and we need to continue to build upon the work being done worldwide.

 
This research confirms the urgent need for policymakers, healthcare providers, clinicians, and researchers to work together to implement robust national sepsis strategies, as called for in the 2017 WHO Resolution on Sepsis.
— Konrad Reinhart, President Global Sepsis Alliance
 

This research was funded by The Bill & Melinda Gates Foundation, the National Institutes of Health (grants T32HL007287, T32HL007820, R35GM119519), the University of Pittsburgh, the British Columbia Children’s Hospital Foundation, the Wellcome Trust, and the Fleming Fund. Of the 23 authors that contributed to this paper, 4 are members of the Executive Committee of the Global Sepsis Alliance.

 

Download Press Release + Q&A (PDF)


Download Template for Press Release + Q&A (editable)


Hendrick.png

For international media inquires, please contact Kathryn Hendrick.

Kathryn.Hendrick@global-sepsis-alliance.org

+1 416 277 6281

Marvin Zick